Yifei Xu

The major work is exploring the expression characteristics of plasma exosome miRNAs associated with various complications (such as hemophagocytic syndrome and mononucleosis) after EB virus infection. Through high-throughput sequencing and bioinformatics analysis, I identified 10 target miRNAs, constructed diagnostic ROC curves, and validated their clinical significance through slow virus transfection in various EB virus-infected cell lines.

In this project, I invested the effects of tuina (Chinese massage) on inflammation and cytokine expression in rat skeletal muscle tissue. Utilizing a mature rat knee joint model, I induced knee arthritis through sodium iodate injection and intervened with tuina. Drawing on literature, I proposed the hypothesis that tuina might intervene in rat muscle inflammation through the PD-1/PD-L1 axis. Consequently, I established a rat knee arthritis model combined with a PD-1 inhibition group, applying tuina intervention. Post-intervention, I collected skeletal muscle tissues from the affected limb, and conducted ELISA and PCR experiments to measure cytokine and PD-1/PD-L1 gene expression, serving as indicators for muscle inflammation. Behavioral data were collected before and after the intervention to assess the progression of knee arthritis in rats.

I recieved basic training and conducted research under the guidence of Prof. Hui Zhang in diagnostic and prognosis role the INTS family acts in HCC using bioinformatics techeques and conducted the experiments to prove. The paper which I participate as the first author was now submitted to Discover Oncology, under the peer-review stage.

Assisted in maintaining daily laboratory operations, rat and mouse animal imaging (CT and MRI), and rat and mouse husbandry.

Xu Y, Chen Y, Yang Q, Lu Y, Zhou R, Liu H, Tu Y, Shao L. Novel plasma microRNA expression features in diagnostic use for Epstein-Barr virus-associated febrile diseases. Heliyon. 2024 Feb 23;10(5):e26810. doi: 10.1016/j.heliyon.2024.e26810. PMID: 38444478; PMCID: PMC10912469.

Xu Y, Zhu X, Li X, Lu Y, Wu J, Cai W, Zheng J, Wu Z, Guo G. Tuina Intervention in Sodium Monoiodoacetate Injection-Induced Rat Model of Knee Osteoarthritis. J Vis Exp. 2024 Jan 12;(203). doi: 10.3791/65770. PMID: 38284553.

Xu Y, Liao W, Wang T, Zhang L, Zhang H. Comprehensive bioinformatics analysis of integrator complex subunits: expression patterns, immune infiltration, and prognostic signature, validated through experimental approaches in hepatocellular carcinoma. Discov Oncol. 2024 Jun 26;15(1):246. doi: 10.1007/s12672-024-01118-6. PMID: 38926181; PMCID: PMC11208364.